Related Article Overview

Presented:
ACI 2019

Published:
January 2019

Article Title:
BCIS Annual General Meeting – 2019

Summary

BCIS Annual General Meeting 2019

Related Article Overview

Authors:
Haseeb Rahman

Presented:
ACI 2019

Published:
January 2019

Article Title:
Young Investigator Award 2019 – Mechanisms of myocardial ischaemia in the absence of obstructive coronary disease

Mechanisms of myocardial ischaemia in the absence of obstructive coronary disease

Dr Haseeb Rahman, BHF Clinical Research Fellow St Thomas’ Hospital, King’s College London and winner of the BCIS Young Investigator Award 2019, presents his work on the mechanisms of ischaemia in the absence of obstructive epicardial coronary disease.

Related Article Overview

Authors:
Haseeb Rahman

Presented:
ACI 2019

Published:
January 2019

Article Title:
DEBATE – Cardiac Arrest without ST elevation – Who should go to the cath lab immediately?

Mechanisms of myocardial ischaemia in the absence of obstructive coronary disease

Dr Haseeb Rahman, BHF Clinical Research Fellow St Thomas’ Hospital, King’s College London and winner of the BCIS Young Investigator Award 2019, presents his work on the mechanisms of ischaemia in the absence of obstructive epicardial coronary disease.

Related Article Overview

Authors:
SL Chen, JJ Zhang

Published:
November 2017

Journal:
J Am Coll Cardiol

Article Title:
DOUBLE KISSING CRUSH VERSUS PROVISIONAL STENTING FOR LEFT MAIN DISTAL BIFURCATION LESIONS DKCRUSH-V RANDOMIZED TRIAL

DOI:
http://dx.doi.org/10.1016/j.jacc.2017.09.1066

A Literature Review by BCIS R&D Group

There are varying PCI techniques for unprotected distal left main (ULM) disease including single stent strategy, provisional T-stenting (PS), crush technique, or culotte. No trial had previously compared DK crush with PS in the context of ULM disease. The DKCRUSH-V randomized trial was a prospective, randomised, international, multicentre study of 482 patients with distal ULM disease scheduled to undergo PCI to evaluate the comparative outcomes of DK crush with PS. The main inclusion criteria were silent ischemia, stable or unstable angina, MI>24 hours before treatment, distal left lesion (Medina 1,1,1 or 0,1,1) with >50% stenosis of both the ostial Cx and LAD by visual assessment.

The primary end point was target lesion failure defined as the composite of cardiac death, target vessel MI, or clinically driven target lesion revascularization at 1 year follow-up. Secondary end point included all cause death, all MI, periprocedural troponin I release, clinically driven revascularization, angina, and in-stent restenosis. In this study, DK crush was associated with a significantly lower primary end point (5% vs. 10.7%; p=0.02). DK crush was also associated with lower rates of target vessel MI (0.4% vs. 2.9%; p=0.03). Clinically driven target vessel revascularization (3.8% vs. 7.9%; p=0.06) and angiographic restenosis (7.1% vs. 14.6%; p=0.1) were numerically lower with DK crush.

In this randomised trial, DK CRUSH was associated with a superior outcome compared to PS in LM PCI.

Related Article Overview

Published:
January 2019

Article Title:
Percutaneous Coronary Intervention In Stable Angina (ORBITA): A Double-Blind, Randomised Controlled Trial

Summary

BCIS Annual General Meeting 2019