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5 January 2017

Endothelial Repopulation, or Not?

Keith Channon

Understanding the mechanisms of endothelial activity in coronary arteries post stenting

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Summary

Discussion on stent histopathology and endothelial function following percutaneous coronary intervention. Key concepts such as the capture of endothelial progenitor cells (EPC) and stent strut coverage are outlined. Data from clinical trials of statin therapy demonstrating an increase in circulating EPC and pre-clinical transgenic mouse models, highlighting the influence of selective endothelial activation on healing and neointima post-stenting, are presented.

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Summary

Discussion on stent histopathology and endothelial function following percutaneous coronary intervention. Key concepts such as the capture of endothelial progenitor cells (EPC) and stent strut coverage are outlined. Data from clinical trials of statin therapy demonstrating an increase in circulating EPC and pre-clinical transgenic mouse models, highlighting the influence of selective endothelial activation on healing and neointima post-stenting, are presented.

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